![]() It is based around a hair follicle containing a keratotic (scaly) plug. The smallest DSAP lesion is a 1–3 mm conical papule, skin coloured, brownish-red or brown in colour. The visibility of this rim is markedly accentuated by the application of an artificial tanning solution ( dihydroxyacetone). The lesions are composed of multiple irregular roundish, annular or polycyclic plaques, each of which has an elevated horny rim. New lesions have been provoked by ultraviolet light in sun lamps. The forehead and cheeks are affected in less than 10% of individuals and DSAP almost never occurs on the scalp, palms or soles. It tends to be more prominent in the summer and may appear less prominent in winter. What are the clinical features of d isseminated superficial actinic porokeratosis?ĭSAP mainly affects the lower arms and legs bilaterally and arises more frequently on the lower legs. These result in decreased cholesterol in the affected areas of the skin. The causative genes in porokeratosis have included the mevalonate pathway genes MVD, MVK, FDPS and PMVK. What causes d isseminated superficial actinic porokeratosis?ĭSAP is due to a genetic mutation. The tendency to DSAP is inherited as an autosomal dominant characteristic, which means on average half of the children of an affected parent will also have the tendency. Its onset can also be triggered by sun exposure, phototherapy, injury, infection or systemic disease. It is rare in childhood.ĭSAP may arise in immune-suppressed patients, including after organ transplantation. The average age at which patients first notice DSAP is about 35–40 years and its frequency in affected families increases steadily with age. Who gets disseminated superficial actinic porokeratosis?ĭSAP most often affects people of European descent, although it has also been reported to affect individuals of other races. ![]()
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